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A Viable Coal-to-Liquids Project?
New Jobs from Clean Energy Can Revitalize the Economy
Coral Reefs in Decline
Conference Call: AB 32 – Where the Rubber Meets the Road
Gas Prices Too High? Take the Bus!
Mapping the Green Economy
Court Denies Petition to Compel EPA Compliance with Supreme Court
Victory in California: Prop 98 Defeated!
California’s Dangerous "Proposition 98"
Conference Call: Can Congress Change Climate?
Global Warming Bill in Connecticut
In Vitro Risk Assessment for a Nano Fuel Additive: Tanks or No Tanks?
By John Balbus
John Balbus, M.D., M.P.H., is Chief Health Scientist.
The history of health and environmental impacts of fuel additives is not a pretty one. From tetra-ethyl lead to methyl tert-butyl ether (MTBE), we’ve learned the hard way that what goes in the tank ends up in our bodies and the environment sooner or later. Getting a thorough understanding of the potential risks of a new fuel additive at an early stage is essential to avoid a lot of harm, suffering, and economic costs down the line.
A new study by Park et al. has assessed the potential respiratory risks of a fuel additive called Envirox (nanoparticulate cerium oxide), giving it a clean bill of health based only on in vitro tests. Is this the vision of the future of risk assessment? Should we feel safe?
Nanoparticulate cerium oxide is touted as a solution to both global warming and particulate air pollution. Added to diesel fuel as a combustion catalyst, it has been shown to reduce both fuel consumption and fine particle concentration in diesel exhaust. But what happens when these tiny particles of cerium oxide blow out of the tail pipe?
The study by Park et al. uses short-term in vitro assays and exposure data to conclude negligible risk of oxidative stress and pulmonary inflammation from chronic exposure to Envirox-augmented diesel exhaust. The authors note that they have only examined oxidative stress and pulmonary inflammation and do not generalize more broadly about other potential health risks.
But does this really show Envirox is safe? The authors note, “this assessment assumes that the in vitro exposure data can be accurately projected to the in vivo situation.” What they don’t say is that it also assumes that short-term in vitro tests accurately predict effects from chronic exposure. Neither of these assumptions is seriously examined in the paper’s discussion, and I’ve questioned whether current in vitro tests can be relied upon to predict actual toxicity in a previous blog. But let’s assume for the moment that these assumptions are true.
Part of the concern with nanoparticles is the potential for translocation around the body, including to places where larger particles cannot go. Could cerium oxide nanoparticles reach and build up in the bone, kidneys, or spleen (areas where non-nano cerium oxide particles accumulate)? What about the developing brain (which other nanoparticles have been shown to access)? Can they harm those organs over time? Unfortunately, exposing lung slices in a petri dish can’t tell us about translocation or harm to these other organs.
In the 1920s, tetra-ethyl lead got the green light as a gasoline additive after a short-term test of effects in adults showed no harm. Of course, the worst effects of its use were chronic effects in children. More than twenty years after lead was taken out of gasoline, children are still affected by residual lead contamination in urban soils. We should be much smarter now.
Even if the present study can be extrapolated to suggest it is unlikely that Envirox will cause pulmonary oxidative stress and related harm in real people, we need to know much more than that before concluding that its widespread use as a fuel additive is safe.
Voinovich Bill: Detailed Prescription for Doing Nothing
Conference Call: Congestion Pricing Is Moving Faster Than Traffic Through Midtown!
For Now, No Congestion Pricing in NYC
Conference Call: Global Warming Mobilization
Legal Action to Compel EPA Compliance with Supreme Court
Sequestering Carbon Deep Within the Earth
Nanoparticles on the brain?
By John Balbus
John Balbus, M.D., M.P.H., is Chief Health Scientist.
It’s been a worry for engineered nanoparticles. Now, a new study from the Harvard School of Public Health (Suglia et al., 2008) is the first to suggest that particulate air pollution not only damages the lungs and heart, but also may damage the developing brain.
Researchers measured cognitive function in over 200 children in Boston in relation to their residential exposure to traffic-related air pollution by measuring airborne carbon black particles. They found the IQ-lowering effect of higher exposure is comparable to a pregnant mother smoking 10 cigarettes a day or moderate lead exposure.
It’s important to note that carbon black is only used as an indicator for traffic-related particle pollution in this study, and the authors stress that it should not be concluded that pure carbon black is the causative agent here. The actual particles inhaled are likely to be contaminated by heavy metals and other toxins, and these may well be the culprits or at least greatly contribute to the actual damage to brain tissues. But it does suggest that some of the ultrafine fraction of air pollution finds its way into the brain and causes harm.
This study may not be making headlines in the nanoworld, but the nanoworld should be taking notice.
The authors hypothesize that the combustion particles make their way via the olfactory nerves from the children’s nasal passages directly into the children’s brains, as has been demonstrated for a variety of engineered nanoparticles in animal models (e.g., Oberdorster et al., 2004; Elder et al., 2006). Once there, the particles, including attached contaminants, may cause oxidative stress, ultimately leading to inflammation and cellular malfunction and/or damage. The study did control for potentially confounding factors like maternal cigarette smoking, lead levels in the children’s blood, mother’s educational level, low birth weight, and other factors.
This study should give pause to those who are making nanoparticles containing known neurotoxins, such as lead and manganese. And with growing understanding of the linkages between developmental and degenerative diseases of the brain, there’s reason to think that processes that lead to IQ loss in growing kids can impair brain functioning in aging adults. One more reason to avoid inhalation of nanoparticles, especially those with known capacity to cause oxidative stress.
Conference Call: Biofuels – the Great Green Hope?
By EDF Blogs
The Energy Bill of 2007 mandates the production of 36 billion gallons of alternative fuels by 2022. What does that mean for the environment? Will food costs skyrocket? And how about our greenhouse gases? As Environmental Defense presses for effective national climate legislation, how will the politics of biofuels impact the legislative battle?
This call was held on Monday, March 3, 2008 at 1:00 PM Eastern.
Featuring- David Yarnold, Executive Director
- Robert Bonnie, Co-Director of Land, Water & Wildlife Program
- Steve Cochran, National Climate Campaign Director
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