Chemical Testing in the 21st Century: Additional Resources

On this page, you will find a collection of links and related reading about new approaches for evaluating chemical hazard and risk that are being developed by the U.S. Environmental Protection Agency (EPA) and other federal entities, including the National Institute of Environmental Health Sciences (NIEHS).   The content is organized into several subsections (see below).  We hope that these resources will both further your understanding of new chemical testing approaches and serve as a reference for future research and engagement.

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General Information


Related Reports

Select Technical Publications

To access all publications from EPA’s Computational Toxicology Program, visit:
New Methods for Evaluating Chemicals
Understanding Chemical Exposure
Building Predictive Models Of Chemical Toxicity
Aggregate Chemical Information and Databases

CompTox Chemical Information Databases

  • Aggregated Computational Toxicology Online Resource (ACToR) – ACToR is a repository of all publicly available chemical toxicity data.  It also houses information related to chemical risk to human health and the environment.  This database contains information on over 500,000 chemicals from more than 650 public sources.
  • Distributed Structure-Searchable Toxicity Database Network (DSSTox) – DSSTox is an online public database of standardized chemical structures that are linked to “high-interest” toxicity data sets.
  • Toxicity Reference Database (ToxRefDB) – ToxRefDB contains data on hundreds of chemicals, mostly pesticides, compiled from thousands of traditional in vivo animal toxicity studies.  To date, the studies in ToxRefDB are primarily regulatory “guideline” studies that follow standardized protocols.
  • Toxicity Forecaster Database (ToxCastDB) – The ToxCast database is being built to house data on thousands of chemicals being run through the hundreds of HT screening assays in ToxCast.  Only a subset of the ToxCast data is currently available.
  • Exposure-Based Chemical Prioritization Database (ExpoCastDB) – The ExpoCastDB contains measurements of the levels of chemicals in environmental and biological media collected from homes and childcare centers.  Data currently available include, to varying degrees, the amounts of these chemicals found in or on food, drinking water, air, dust, indoor surfaces and urine.  The public version of ExpoCastDB currently includes limited exposure data for 99 chemicals, mostly pesticides.


National Academies’ Standing Committee on Use of Emerging Science for Environmental Health Decisions

Additional Resources/Information